KMID : 0605720160220030187
|
|
Journal of the Korean Society of Biological Therapies in Psychiatry 2016 Volume.22 No. 3 p.187 ~ p.195
|
|
Relationship between Sleep Disturbance and Cognitive Dysfunction in Patients with Mild Cognitive Impairment
|
|
Lim Chan-Young
Shin Il-Seon Shin Hee-Young Kim Jae-Min Kim Sung-Wan Yoon Jin-Sang
|
|
Abstract
|
|
|
Objectives£ºThe relationship between sleep disturbance and cognitive dysfunction in patients with mild cognitive impairment (MCI) has been reported, but relatively few studies have explored the relationship. This study attempted to investigate the association between sleep disturbance and cognitive dysfunction in MCI patients.
Methods£ºSeventy eight MCI patients were assessed with a comprehensive neuropsychological test battery (Seoul Neuropsychological Screening Battery-2, SNSB-2). To assess behavioral and psychological symptoms, including sleep disturbance, Neuropsychiatric Inventory(NPI) was used.
Results£ºKorean version of Mini-Mental State Exam(K-MMSE) score was significantly lower in the group with sleep disturbance(n=31) than the group without sleep disturbance(n=47)(p=0.046). After adjusted for K-MMSE scores by ANCOVA, the group with sleep disturbance had significantly lower performance scores in Calculation-sub, Ideomotor apraxia than the group without sleep disturbance(p=0.029, p=0.019). Additionally, non-amnestic MCI group with sleep disturbance had significantly lower performance scores in Calculation-sub, Rey Complex Figure Test-immediate recall than non-amnestic MCI group without sleep disturbance p=0.036, p=0.026).
Conclusion£ºThe group with sleep disturbance showed cognitive dysfunction in language and related function as compared to the group without sleep disturbance in patients with MCI.
|
|
KEYWORD
|
|
Mild cognitive impairment, Sleep disturbance, Cognitive function
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|